Donald Trump swerved a question from a reporter suggesting he had consistently lied to the American people during his presidency.
"Mr President... after three and a half years, do you regret at all, all the lying you've done to the American people?," asked S.V Date, a veteran journalist for the Huffington Post.
Mr Trump asked the correspondent to clarify his question, to which he replied: "All the lying. All the dishonesties."
"That who has done?," asked a still confused president.
Mr Date made clear that he was asking about Mr Trump himself, prompting the president to turn his gaze to another journalist and give them the chance to ask a question instead, without offering up an answer or defence.
"Go ahead, please," the president repeated, keen to move on from his exchange with Mr Date.
After the briefing, Mr Date, who has long urged White House journalists to push back against the president's claims, tweeted: "For five years I've been wanting to ask him that."
Previously, an investigation by The Washington Post claimed that Mr Trump had made more than 20,000 false or misleading statements since he took office in January 2017.
His record is under ever-increasing scrutiny as COVID-19 continues to spread throughout much of the US, which has more confirmed cases than any other country with just shy of 5.3 million.
More than 167,250 people have died with COVID-19 in the US, which is also the highest count globally, according to Johns Hopkins University, which is tracking the pandemic.
Mr Date also tweeted that Mr Trump was using his news briefing to deliver a partisan campaign speech, which he suggested could be in violation of the law if White House staff had been involved.
The president took aim at Kamala Harris during the briefing, amplifying a conspiracy theory that Joe Biden's running mate for the upcoming election was not born in the US and therefore unqualified to serve as vice president.
Ms Harris - who earlier this week became the first woman of colour to be nominated for national office by a major US political party - was born in Oakland, California.
Mr Trump previously questioned whether Barack Obama was eligible to be president for the same reason, and only stopped after his predecessor released a birth certificate proving that he was born in Hawaii.